11 beta hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess

The mechanism by which the glycyrrhizinates exert their effect on the renin-angiotensin-aldosterone system has been elucidated. 2 , 35 , 36 , 42 Competitive (and reversible) inhibition of the enzyme 11-beta-hydroxysteroid dehydrogenase results in the suppression of cortisol conversion to inactive cortisone. Consequent suppression of plasma renin activity and aldosterone levels is evident. Exchangeable sodium levels increase and cortisol occupation of mineralocorticoid receptors in the distal kidney tubules is enhanced. The condition responds to administration of spironolactone, potassium supplementation, and discontinuation of licorice.

Earlier age hair loss and hair graying are a sign of overall rapid body ageing in some (but definitely far from all) people. In the latest BBC article that I linked to above, one of the scientists quoted suggests that DNA damage from ageing was a potential reason for early onset hair loss, early onset hair graying and early onset heart disease. Of course there are many people who go bald or grey very early and live to be over a 100 with no signs of heart disease…probably because they have certain genetic protections (., high HDL “good” cholesterol levels ) towards heart disease.

In a Caucasian boy with HSD10MD, Falk et al. (2016) identified a hemizygous missense mutation in the HSD17B10 gene (K212E; ). No parental DNA or DNA from reportedly affected maternal uncles was available for study. In vitro functional expression assays showed that the mutation resulted in decreased dehydrogenase activity. However, more significantly, the mutation disrupted TRMT10C ( 615423 )-associated methyltransferase activity and destabilized the RNase P holoenzyme, resulting in impaired mitochondrial tRNA processing and maturation and impaired mitochondrial protein synthesis. The findings suggested that the major pathogenic mechanism resulting from HSD17B10 mutations is the adverse effect on mitochondrial function.

I was reading in the university health news daily website that a study performed by researchers at the University of Texas . Anderson Cancer Center found that men with prostate cancer who ate 3 tablespoons of milled or ground flax seeds each day had decreased prostate cancer cell proliferation compared to similar men who did not eat flax seeds. According to the American Cancer Society, men who supplement their diets with flax seed have lower PSA levels and slower growth of benign as well as cancerous prostate cells.
Perhaps the effect of phytoestrogenic in humans it’s not fully understood as yet.
Cheers

11 beta hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess

11 beta hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess

I was reading in the university health news daily website that a study performed by researchers at the University of Texas . Anderson Cancer Center found that men with prostate cancer who ate 3 tablespoons of milled or ground flax seeds each day had decreased prostate cancer cell proliferation compared to similar men who did not eat flax seeds. According to the American Cancer Society, men who supplement their diets with flax seed have lower PSA levels and slower growth of benign as well as cancerous prostate cells.
Perhaps the effect of phytoestrogenic in humans it’s not fully understood as yet.
Cheers

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11 beta hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess11 beta hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess11 beta hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess11 beta hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess11 beta hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess

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