Do not use Vigamox if you have a viral or fungal infection in the eye. It is used to treat infections caused by bacteria only. Do not use this medicine if you have had an allergic reaction to it or other similar medicines in the past. Medicines similar to Vigamox include gatifloxacin ophthalmic (Zymar), gatifloxacin (Tequin), ciprofloxacin ophthalmic (Ciloxan), ciprofloxacin (Cipro), ofloxacin ophthalmic (Ocuflox), ofloxacin (Floxin), norfloxacin ophthalmic (Chibroxin), norfloxacin (Noroxin), levofloxacin ophthalmic (Quixin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), sparfloxacin (Zagam), trovafloxacin (Trovan), and moxifloxacin (Avelox).
Because P. aeruginosa and S. aureus are common pathogens in otorrhea, they must be considered at the time of treatment selection. Currently, no narrow-spectrum agent is available for the coverage of these two microbes. For the treatment of acute diffuse otitis externa, polymyxin B-neomycin-hydrocortisone combinations and fluoroquinolones are equally effective, and neither treatment carries known risk. The twice-daily dosing schedule of topical fluoroquinolones may improve compliance. When selecting treatment for acute otitis media with perforation, topical fluoroquinolones represent a good first-line option, although not clearly better than traditional topical therapy. For chronic suppurative otitis media topical fluoroquinolones likely represent the best choice because treatment is long, and repeated therapy is common. 18