mg orally once a day.
to mg/day (transdermal film) applied topically 1 or 2 times a week. Systems should not be applied to the breasts.
14 mcg/day weekly (transdermal film) applied topically once a week.
Application sites vary according to manufacturer formulation and include the lower abdomen, upper thigh, buttocks, or upper arm.
In addition to hormonal therapy, adequate calcium intake is important for postmenopausal women who require treatment or prevention of osteoporosis. The average diet of older American women contains 400 to 600 mg of calcium per day. A suggested optimal intake is 1500 mg per day. If dietary intake is insufficient to achieve 1500 mg per day, supplementation may be useful in women who have no contraindication to calcium supplementation.
Long-term therapy (for more than 5 years) is generally necessary in order to obtain substantive benefits in reducing the risk of bone fracture. Maximal benefits are obtained if estrogen therapy is initiated as soon after menopause as possible. The optimal duration of therapy has not been definitively determined.
Women currently on oral estrogen therapy and changing to a transdermal estradiol system should initiate transdermal therapy 1 week following discontinuation of oral estrogens (sooner if menopausal symptoms reappear). Changes between transdermal systems may be initiated without interruption of therapy.
When used solely for the prevention of postmenopausal osteoporosis, approved non-estrogen treatments should carefully be considered, and estrogen and combined estrogen-progestin products should only be considered for women with significant risk of osteoporosis that outweighs the risks of the drug.
Purabi Sarkar is currently pursuing her PhD in Biotechnology from Gauhati University under the supervision of Dr. Sofia Banu. She has completed her Masters in Biotechnology from Bengaluru University and Post Graduate Diploma in Advanced Clinical Research from ICRI, Bengaluru. She has worked as Research Trainee at R&D Centre, Indian Immunologicals Ltd, Hyderabad under the DBT-BCIL training program. She has published three article in International Journals (includes Elsevier publications) and 2 popular paper articles. She has presented her work in two international conferences and two national conferences.