Given the nature of many of the androgenic and estrogenic side effects from Trenbolone, it is often difficult to minimize the risk of negative effects while still preserving the efficacy of the drug. There are certainly methods that bodybuilders use to minimize the likelihood of harmful reactions, and the most important would be only taking anabolic-androgenic steroids under the supervision of a doctor who is well-versed in steroid use.
I think that if most bodybuilders objectively consider the long-term risks versus the short-term gains, it really won’t seem worth it in the end.
Injectable steroids are injected into muscle tissue, not into the veins. They are slowly released from the muscles into the rest of the body, and may be detectable for months after last use. Injectable steroids can be oil-based or water-based. Injectable anabolic steroids which are oil-based have longer half-life than water-based steroids. Both steroid types have much longer half-lives than oral anabolic steroids. And this is proving to be a drawback for injectables as they have high probability of being detected in drug screening since their clearance times tend to be longer than orals. Athletes resolve this problem by using injectable testosterone early in the cycle then switch to orals when approaching the end of the cycle and drug testing is imminent.
Some bodybuilders and athletes use trenbolone esters for their muscle-building and otherwise performance-enhancing effects.  Such use is illegal in the United States and many other countries. The DEA classifies trenbolone and its esters as Schedule III controlled substances under the Controlled Substances Act .  Trenbolone is classified as a Schedule 4 drug in Canada  and a class C drug with no penalty for personal use or possession in the United Kingdom .  Use or possession of steroids without a prescription is a crime in Australia .