Our evaluation is primarily based on an independent scientific review of the evidence on the effectiveness, safety, and adverse effects of NSAIDs, along with periodic review of research updates. A team of physicians and researchers at the Oregon Health & Science University Evidence-Based Practice Center conducted the analysis as part of the Drug Effectiveness Review Project, or DERP. DERP is a first-of-its-kind multi-state initiative to evaluate the comparative effectiveness and safety of hundreds of prescription drugs. A synopsis of DERP’s analysis of the NSAIDs forms the basis for this report. A consultant to Consumer Reports Best Buy Drugs is also a member of the Oregon-based research team, which has no financial interest in any pharmaceutical company or product.
inhibition.) On the other hand, aspirin forms a covalent bond to a serine residue in the enzyme, and this bond cannot be broken. (This is called irreversible inhibition.) Acetaminophen does not interact with either COX-1 or COX-2, but it is now understood that it may interact with a newly identified cyclooxygenase, COX-3. Selective targeting of the COX enzymes is an exciting area of pharmacology, in which the challenge continues to be the development of drugs that interact with specific COX enzymes.