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351 subjects with moderate psoriasis were randomized to DFD-01 (n=174), Diprolene (n=90), or Vehicle (n=87). Mean BSA was 13-14%. Treatment success was achieved in % DFD-01, % Diprolene, and % Vehicle (P< DFD-01 vs Vehicle) at day 15. Treatment success at day 8 was 10% DFD-01, % Diprolene, and % Vehicle (P= DFD-01 vs Vehicle). TSS was significantly reduced with DFD-01 compared with Vehicle at days 4, 8, and 15 (P ≤ ) and compared with Diprolene at day 4 (P=). DFD-01 relieved signs of erythema and scaling earlier than Diprolene or Vehicle, showing significant improvements on day 4 (P ≤ ). All products were well tolerated. Significantly more burning/stinging was reported with Diprolene than DFD-01 (% vs %, P=).

Why are different strengths critical? The appropriate strength depends on many factors. For example, babies absorb topical steroids faster than adults, so they may require a low-potency steroid. Areas of the body where skin touches skin (think: armpits, rectal area, etc), as well as sensitive areas (like the skin on the eyelids), tend to absorb topical steroids more rapidly, so those regions of the body also usually require a low-potency steroid. However, thick, rough skin on the palms of the hands and the soles of the feet usually absorb topical steroids more slowly than other parts of the body, so those areas typically require a more potent steroid. Keep in mind: The greater the potency of the steroid (in other words, the lower its class number), the more likely it is to cause side effects .

The most commonly used AAS in medicine are testosterone and its various esters (but most commonly testosterone undecanoate , testosterone enanthate , testosterone cypionate , and testosterone propionate ), [53] nandrolone esters (most commonly nandrolone decanoate and nandrolone phenylpropionate ), stanozolol , and metandienone (methandrostenolone). [1] Others also available and used commonly but to a lesser extent include methyltestosterone , oxandrolone , mesterolone , and oxymetholone , as well as drostanolone propionate , metenolone (methylandrostenolone), and fluoxymesterone . [1] Dihydrotestosterone (DHT; androstanolone, stanolone) and its esters are also notable, although they are not widely used in medicine. [54] Boldenone undecylenate and trenbolone acetate are used in veterinary medicine . [1]

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