Non steroidal inhalers for asthma

Biswal, Thimmulappa, and the Johns Hopkins University hold intellectual property on the development of Nrf2-based therapeutics in COPD, and they have equity in Cureveda LLC, which was co-founded by Biswal and Thimmulappa, and where they serve as scientific consultants. These potential individual and institutional conflicts of interest have been reviewed and managed by the Johns Hopkins Bloomberg School of Public Health. Under a licensing agreement between Brassica Protection Products and the Johns Hopkins University, the University is entitled to royalty received on sales of products/technology described in this article. The University owns Brassica Protection Products stock, which is subject to certain restrictions under University policy. The terms of this arrangement are being managed by the Johns Hopkins University in accordance with its conflict of interest policies. No other competing interest were declared.

Glucocorticoids are potent anti-inflammatories, regardless of the inflammation's cause; their primary anti-inflammatory mechanism is lipocortin-1 (annexin-1) synthesis. Lipocortin-1 both suppresses phospholipase A2 , thereby blocking eicosanoid production, and inhibits various leukocyte inflammatory events ( epithelial adhesion , emigration , chemotaxis , phagocytosis , respiratory burst , etc.). In other words, glucocorticoids not only suppress immune response, but also inhibit the two main products of inflammation, prostaglandins and leukotrienes . They inhibit prostaglandin synthesis at the level of phospholipase A2 as well as at the level of cyclooxygenase /PGE isomerase (COX-1 and COX-2), [29] the latter effect being much like that of NSAIDs , potentiating the anti-inflammatory effect.

SOURCES:
American Academy of Asthma, Allergy & Immunology: "Asthma" and "Allergy and Asthma Drug Guide."
National Jewish Medical and Research Center: "Inhaled Medication with a Metered Dose Inhaler (MDI)." 
Asthma Society of Canada: "How to Use Your Inhaler."
Science Daily: "New Asthma Inhaler Propellant Effective, but Costlier."
Children's Hospital Boston: "Allergy Treatment."
Boehringer Ingelheim: "US FDA Expands Approval of Tiotropium Respimat® for Maintenance Treatment of Asthma in Children."
FDA. Prescribing Information: Spiriva Respimat.

Comments and suggestions welcome!   Email: schumach@
Content Owner:  Michael J. Schumacher, MB, FRACP, The University of Arizona
Updated 3/2012                                                                                                                                   

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Non steroidal inhalers for asthma

non steroidal inhalers for asthma

Comments and suggestions welcome!   Email: schumach@
Content Owner:  Michael J. Schumacher, MB, FRACP, The University of Arizona
Updated 3/2012                                                                                                                                   

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