In patients in whom there is a suspicion of infection within the joint, steroid injections should be avoided. As steroids can alter blood sugar levels, they should be used with caution in patients who have poorly controlled diabetes. They should also be used with caution in patients who are on blood thinning medication such as Aspirin or Warfarin. Patients are usually requested to stop blood thinning medication for a few days before the procedure. Any known allergy to the components of the steroid injections is also an indication to avoid administering it.
How often cortisone injections are given varies based on the reason for the injection. This is determined on a case-by-case basis by the health care practitioner. If a single cortisone injection is curative, then further injections are unnecessary. Sometimes, a series of injections might be necessary; for example, cortisone injections for a trigger finger may be given every three weeks, to a maximum of three times in one affected finger. In other instances, such as knee osteoarthritis, a second cortisone injection may be given approximately three months after the first injection, but the injections are not generally continued on a regular basis.
Addiction to cortisone was the subject of the 1956 motion picture, Bigger Than Life , produced by and starring James Mason . Though it was a box-office flop upon its initial release,  many modern critics hail it as a masterpiece and brilliant indictment of contemporary attitudes towards mental illness and addiction.  In 1963, Jean-Luc Godard named it one of the ten best American sound films ever made.  John F. Kennedy needed to regularly use corticosteroids such as cortisone as a treatment for Addison's disease .