100 mg/m2 IV every 4 weeks in combination with vinorelbine (25 mg/m2 IV) once weekly. Closely monitor CBC and renal function to determine whether a dose reduction of vinorelbine and/or cisplatin is necessary. In the SWOG trial, most patients required a 50% dose reduction of vinorelbine at day 15 of each cycle and a 50% dose reduction of cisplatin by cycle 3. Alternatively, cisplatin 120 mg/m2 IV on days 1 and 29, then every 6 weeks plus vinorelbine (30 mg/m2 IV) weekly may be used. Vinorelbine in combination with cisplatin resulted in significantly improved response rates, progression-free survival and overall survival as compared to patients who received cisplatin alone for the treatment of advanced NSCLC.
Do you find milk addictive? If so, assume an opioid-like peptide reaction. Does milk make you sneeze? If so, assume an intolerance to the immunological compounds and/or opioids, or a genuine allergic reaction – particularly if milk makes your throat itch. Does milk make you gain weight? If so, assume an opioid-like peptide reaction and/or sensitivity to IGF. Does milk provoke seizures? If so, you may need to test your reaction to calcium.
For suspected opioid-like peptide responders, individuals should test A1 milk (regular cow’s milk) versus officially branded A2 milk (Guernsey cow, buffalo, goat’s and sheep’s milk). People who are intolerant of opioids usually tolerate goat’s and sheep’s milk unless they are super-responders. See the gluten and casein responders page . Cream and Butter